Autor: Mathias Christmann
ISBN-13: 9783527329212
Veröffentl: 01.11.2012
Einband: Buch
Seiten: 404
Gewicht: 1068 g
Format: 249x177x30 mm
Sprache: Englisch

Asymmetric Synthesis II

More Methods and Applications
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An illustrious group of international authors provides the reader with the latest research highlights in asymmetric synthesis. Both graduate students and advanced researchers will profit from a unique coverage of topics including industrial applications.
InhaltsangabeCATALYTIC ENANTIOSELECTIVE ALKYLATION OF PROCHIRAL KETONE ENOLATES Background Strategy and Results Asymmetric Allylic Alkylation in Total Synthesis Conclusions POINTTOPLANAR CHIRALITY TRANSFER IN TOTAL SYNTHESIS: SCALABLE AND PROGRAMMABLE SYNTHESIS OF HAOUAMINE A AND ITS ATROPISOMER Introduction Synthetic Strategy Featuring Point-to-Planar Chirality Transfer Programmable Synthesis of Haouamine A and Its Atropisomer TETHERED AMINOHYDROXYLATION Introduction and Background Tethered Aminohydroxylation AmideBased Reoxidants Evidence for the Mechanism of the TA Reaction Applications in Organic Synthesis Conclusion and Future Work ORGANOCATALYZED TRANSFORMATIONS OF A, B-UNSATURATED CARBONYL COMPOUNDS THROUGH IMINIUM ION INTERMEDIATES THE RENAISSANCE OF SILICON-STEREOGENIC SILANES: A PERSONAL ACCOUNT Background Results Conclusion ASYMMETRIC DIENAMINE ACTIVATION Introduction Historic Background Results Conclusion ASYMMETRIC BRØNSTED ACID CATALYSIS Introduction and Background Strategy Results Summary QUATERNARY STEREOGENIC CENTERS BY ENANTIOSELECTIVE B-CARBON ELIMINATIONS FROM TERT-CYCLOBUTANOLS Background Objective: Enantioselective Formation of Quaternary Stereogenic Centers in Combination with Reactive Alkyl-Rhodium Intermediates Selective Generation of the Alkyl-Rhodium Species and Its Downstream Reactivities TOTAL SYNTHESIS OF OSELTAMIVIR AND ABT-341 USING ONE-POT TECHNOLOGY Introduction Results Conclusions ENANTIOSELECTIVE ANNULATIONS WITH CHIRAL N-MESITYL N-HETEROCYCLIC CARBENES Introduction Catalytic Generation of Chiral Enolate Equivalents Catalytic Generation of Homoenolate Equivalents Enantioselective Cascade Reactions Catalyzed by Chiral N-Heterocyclic Carbenes Catalytic Annulations via a, ß-Unsaturated Acyl Azoliums Conclusions ASYMMETRIC COUNTERANION-DIRECTED CATALYSIS (ACDC) Concept Application of ACDC to Organocatalysis Application of ACDC to Transition Metal Catalysis Application of ACDC to Lewis Acid Catalysis ENANTIOSELECTIVE ORGANO-SOMO CATALYSIS: A NOVEL ACTIVATION MODE FOR ASYMMETRIC SYNTHESIS Background Objective Results ENANTIOSELECTIVE PASSERINI REACTION Introduction Background Results Conclusion and Perspective RAPID ENANTIOMERIC EXCESS DETERMINATION ASYMMETRIC CATALYSIS OF REVERSIBLE REACTIONS Thermochemistry of Asymmetric Catalyses Close to the Equilibrium Kinetic Modeling of a Reversible Asymmetric Catalytic Reaction Case Study: a Reversible Asymmetric Organocatalytic Reaction Conclusions EXPLOITING FLUORINE CONFORMATIONAL EFFECTS IN ORGANOCATALYST DESIGN: THE FLUORINE?IMINIUM ION GAUCHE EFFECT DUTCH RESOLUTION CONSTRUCTION OF ANTI-ME-OH VICINAL RELATIONSHIPS IN POLYKETIDES Introduction Marshall Tamaru Reaction Conclusions PHOTOSWITCHABLE GENERAL BASE CATALYSTS Introduction and Background Strategy and Results Outlook ASYMMETRIC HALONIUM ADDITION TO OLEFINS Introduction Intramolecular Lactonizations, Etherifications, and Aminations Polyene Cyclizations Intermolecular Additions to Alkenes Conclusion CATALYTIC ASYMMETRIC GOSTELI - CLAISEN REARRANGEMENT (CAGC) BIOMIMETIC TOTAL SYNTHESIS OF THE PENIFULVIN FAMILY Introduction The Penifulvin Family: Isolation and Biogenetic Origin Total Syntheses of Penifulvins A, B, and C Summary CATALYSTCONTROLLED 1,3POLYOL SYNTHESES ENANTIOSELECTIVE CARBONYL ALLYLATION AND CROTYLATION FROM THE ALCOHOL OXIDATION LEVEL VIA C?C BOND FORMING TRANSFER HYDROGENATION Introduction and Background Strategy Results STEREOSELECTIVE SYNTHESIS WITH HYPERVALENT IODINE REAGENTS ASYMMETRIC GOLD-CATALYZED REACTIONS Introduction DiphosphineGold Complexes in Enantioselective Catalysis Monophosphine-Gold Complexes in Enantioselective Catalysis ASYMMETRIC CATALYSIS IN THE TOTAL SYNTHESIS OF LIPIDS AND POLYKETIDES Background Tuberculostearic Acid: On
CATALYTIC ENANTIOSELECTIVE ALKYLATION OF PROCHIRAL KETONE ENOLATES
Background
Strategy and Results
Asymmetric Allylic Alkylation in Total Synthesis
Conclusions
POINT-TO-PLANAR CHIRALITY TRANSFER IN TOTAL SYNTHESIS: SCALABLE AND PROGRAMMABLE SYNTHESIS OF HAOUAMINE A AND ITS ATROPISOMER
Introduction
Synthetic Strategy Featuring Point-to-Planar Chirality Transfer
Programmable Synthesis of Haouamine A and Its Atropisomer
TETHERED AMINOHYDROXYLATION
Introduction and Background
Tethered Aminohydroxylation
Amide-Based Reoxidants
Evidence for the Mechanism of the TA Reaction
Applications in Organic Synthesis
Conclusion and Future Work
ORGANOCATALYZED TRANSFORMATIONS OF A, B-UNSATURATED CARBONYL COMPOUNDS THROUGH IMINIUM ION INTERMEDIATES
THE RENAISSANCE OF SILICON-STEREOGENIC SILANES: A PERSONAL ACCOUNT
Background
Results
Conclusion
ASYMMETRIC DIENAMINE ACTIVATION
Introduction
Historic Background
Results
Conclusion
ASYMMETRIC BRØNSTED ACID CATALYSIS
Introduction and Background
Strategy
Results
Summary
QUATERNARY STEREOGENIC CENTERS BY ENANTIOSELECTIVE B-CARBON ELIMINATIONS FROM TERT-CYCLOBUTANOLS
Background
Objective: Enantioselective Formation of Quaternary Stereogenic Centers in Combination with Reactive Alkyl-Rhodium
Intermediates
Selective Generation of the Alkyl-Rhodium Species and Its Downstream Reactivities
TOTAL SYNTHESIS OF OSELTAMIVIR AND ABT-341 USING ONE-POT TECHNOLOGY
Introduction
Results
Conclusions
ENANTIOSELECTIVE ANNULATIONS WITH CHIRAL N-MESITYL N-HETEROCYCLIC CARBENES
Introduction
Catalytic Generation of Chiral Enolate Equivalents
Catalytic Generation of Homoenolate Equivalents
Enantioselective Cascade Reactions Catalyzed by Chiral N-Heterocyclic Carbenes
Catalytic Annulations via a, ß-Unsaturated Acyl Azoliums
Conclusions
ASYMMETRIC COUNTERANION-DIRECTED CATALYSIS (ACDC)
Concept
Application of ACDC to Organocatalysis
Application of ACDC to Transition Metal Catalysis
Application of ACDC to Lewis Acid Catalysis
ENANTIOSELECTIVE ORGANO-SOMO CATALYSIS: A NOVEL ACTIVATION MODE FOR ASYMMETRIC SYNTHESIS
Background
Objective
Results
ENANTIOSELECTIVE PASSERINI REACTION
Introduction
Background
Results
Conclusion and Perspective
RAPID ENANTIOMERIC EXCESS DETERMINATION
ASYMMETRIC CATALYSIS OF REVERSIBLE REACTIONS
Thermochemistry of Asymmetric Catalyses Close to the Equilibrium
Kinetic Modeling of a Reversible Asymmetric Catalytic Reaction
Case Study: a Reversible Asymmetric Organocatalytic Reaction
Conclusions
EXPLOITING FLUORINE CONFORMATIONAL EFFECTS IN ORGANOCATALYST DESIGN: THE FLUORINE?IMINIUM ION GAUCHE EFFECT
DUTCH RESOLUTION
CONSTRUCTION OF ANTI-ME-OH VICINAL RELATIONSHIPS IN POLYKETIDES
Introduction
Marshall - Tamaru Reaction
Conclusions
PHOTOSWITCHABLE GENERAL BASE CATALYSTS
Introduction and Background
Strategy and Results
Outlook
ASYMMETRIC HALONIUM ADDITION TO OLEFINS
Introduction
Intramolecular Lactonizations, Etherifications, and Aminations
Polyene Cyclizations
Intermolecular Additions to Alkenes
Conclusion
CATALYTIC ASYMMETRIC GOSTELI - CLAISEN REARRANGEMENT (CAGC)
BIOMIMETIC TOTAL SYNTHESIS OF THE PENIFULVIN FAMILY
Introduction
The Penifulvin Family: Isolation and Biogenetic Origin
Total Syntheses of Penifulvins A, B, and C
Summary
CATALYST-CONTROLLED 1,3-POLYOL SYNTHESES
ENANTIOSELECTIVE CARBONYL ALLYLATION AND CROTYLATION FROM THE ALCOHOL OXIDATION LEVEL VIA C?C BOND FORMING TRANSFER HYDROGENATION
Introduction and Background
Strategy
Results
STEREOSELECTIVE SYNTHESIS WITH HYPERVALENT IODINE REAGENTS
ASYMMETRIC GOLD-CATALYZED REACTIONS
Introduction
Diphosphine-Gold Complexes in Enantioselective Catalysis
Monophosphine-Gold Complexes in Enantioselective Catalysis
ASYMMETRIC CATALYSIS IN THE TOTAL SYNTHESIS OF LIPIDS AND POLYKETIDES
Background
Tuberculostearic Acid: One Isolated Methyl Group
Ant Pheromones: Vicinal Methyl Branches
Deoxypropionates: 1,3-Methyl Arrays
Membrane-Spanning Lipids: 1,4-Dimethyl Uni
Eine Gruppe international renommierter Autoren vermittelt die neuesten Forschungsergebnisse im Bereich der asymmetrischen Synthese. Studenten höherer Semester und Forscher finden in diesem Lehrbuch eine einzigartige Themensammlung, u. a. auch zu Anwendungen in der Industrie.
Editiert von: Mathias Christmann, Stefan Bräse
Mathias Christmann is currently working as assistant professor at the university of AachenStefan Braese is a young and successful researcher, working at the University of Karlsruhe. He has published nearly 100 publications and is recipient of the ORCHEM award in 2000

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Autor: Mathias Christmann
ISBN-13:: 9783527329212
ISBN: 3527329218
Erscheinungsjahr: 01.11.2012
Verlag: Wiley VCH Verlag GmbH
Gewicht: 1068g
Seiten: 404
Sprache: Englisch
Sonstiges: Buch, 249x177x30 mm, 286 schwarz-weiße und 1 farbige Abbildungen, 12 schwarz-weiße Tabellen