Autor: Leonardo S. Santos
ISBN-13: 9783527323517
Veröffentl: 01.12.2009
Einband: Buch
Seiten: 317
Gewicht: 778 g
Format: 249x179x29 mm
Sprache: Englisch

Reactive Intermediates

MS Investigations in Solution
 Buch
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Edited by a top expert, this book represents a powerful tool showing how to successfully apply ESI-MS in revealing, elucidating and helping to consolidate several proposed mechanisms of organic reactions that need to be emphasized.
With a foreword by Chris Enke.
Preface
A BRIEF OVERVIEW OF THE MECHANISMS INVOLVED IN ELECTROSPRAY MASS SPECTROMETRY
Introduction
Production of Gas-Phase Ions by Electrospray and Electrospray Ionization Mass Spectrometry
HISTORICAL PERSPECTIVES IN THE STUDY OF ION CHEMISTRY BY MASS SPECTROMETRY: FROM THE GAS PHASE TO SOLUTION
A Brief History and Recent Advances in Mass Spectrometry
Overview of the Study of Ion/Molecule Reactions in the Gas Phase by Mass Spectrometry
Future Perspectives
ORGANIC REACTION STUDIES BY ESI-MS
Introduction
Reaction Mechanisms
General Remarks
STUDIES OF REACTION MECHANISM INTERMEDIATES BY ESI-MS
Introduction
Studies on the Intermediates and Mechanisms of Pd-Catalyzed Reactions
Studies on Some Reactive Intermediates and Mechanisms of Radical Reactions
Studies on the Intermediates and Mechanism of Organocatalysis Reactions
Studies on the Intermediates and Mechanism of Transition Metal-Catalyzed Polymerization Reactions
ON-LINE MONITORING REACTIONS BY ELECTROSPRAY IONIZATION MASS SPECTROMETRY
Introduction
Preservation of the Charge in the Transit of Ions from Solution to the Gas Phase Using the ESI Technique
Developing Methods to Study Reaction Mechanisms
Probing Reactivity of Intermediates
Conclusion
GAS PHASE LIGAND FRAGMENTATION TO UNMASK REACTIVE METALLIC SPECIES
Introduction and Scope of the Review
Unmasking Reactive Metallic Intermediates via Collision-Induced Dissociation
Conclusions
PALLADIUM INTERMEDIATES IN SOLUTION
Introduction
ESI-MS Studies in Suzuki-Miyaura Cross-Coupling and Related Reactions
ESI-MS Studies in the Identification of Oxidative Addition Intermediates
ESI-MS Studies in Mizoroki-Heck and Related Reactions
ESI-MS Studies in Stille Cross-Coupling Reactions
ESI-MS Studies in Palladium-Catalyzed Reactions Involving Allenes
ESI-MS Studies in Palladium-Catalyzed Alkynylation Reactions
ESI-MS Studies in Palladium-Catalyzed Allylic Substitution Reactions
ESI-MS Studies in Palladium-Catalyzed Oxidation of 2-Allylphenols
ESI-MS Studies in Palladium-Catalyzed Polymerization Reactions
Conclusions
PRACTICAL INVESTIGATION OF MOLECULAR AND BIOMOLECULAR NONCOVALENT RECOGNITION PROCESSES IN SOLUTION BY ESI-MS
Introduction
Methods and Applications
Practical Aspects of Titration Analysis
Summary and Outlook
During the last two decades there has been considerable growth in the development of electrospray ionization mass spectrometry (ESI-MS) as a practical method in the study of reaction mechanisms. This method allows the interception and characterization of key intermediates, either as transient species or as protonated/deprotonated forms of neutral species by API-MS. The outstanding features and advantages of ESI-MS make it one of the most suitable tools for the fast screening of intermediates directly from solution, providing hitherto unavailable chemical information to organic chemists.
This monograph provides an overview of the mechanisms involved in ESI-MS, the historical perspectives before looking further in-depth at specific reactions and intermediates. Written by researchers in the field, this book is an unique resource for the understanding of this cutting-edge technique.
Editiert von: Leonardo S. Santos
After being awarded his MSc in 1999 Leonardo Silva Santos joined the Universidade Estadual de Campinas in Brasil for his thesis working on the total synthesis of natural products, while also doing research for two years at the University of Chicago in 2001-2002. After beind awarded his Ph.D. in 2003 he did postdoctoral research at UNICAMP, Brasil, and at the Carl von Ossietzky Universität Oldenburg. He is currently Professor at the Universidad de Talca, Chile.

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Autor: Leonardo S. Santos
ISBN-13:: 9783527323517
ISBN: 3527323511
Erscheinungsjahr: 01.12.2009
Verlag: Wiley VCH Verlag GmbH
Gewicht: 778g
Seiten: 317
Sprache: Englisch
Sonstiges: Buch, 249x179x29 mm