Autor: Paul M. Selzer
ISBN-13: 9783527323272
Veröffentl: 01.04.2009
Einband: Buch
Seiten: 489
Gewicht: 1093 g
Format: 247x182x30 mm
Sprache: Englisch

Antiparasitic and Antibacterial Drug Discovery

1, Drug Discovery in Infectious Diseases
From Molecular Targets to Drug Candidates
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Mainly addressing parasitic diseases but also those caused by bacteria, this much-needed reference provides a unique insight into commercial science s approach to infectious diseases. The authors have first-hand experience of drug discovery units in the pharmaceutical industry.
Preamble
Editor Preface
PART I Drug Discovery Approaches
1 Target identification and mechanism-based screening for anthelmintics: Application of veterinary antiparasitic research programmes to search for new antiparasitic drugs for human indications
2 Anthelmintic resistance as a guide to the discovery of new drugs?
3 Drug discovery for neglected diseases: view of a public-private partnership
4 Bioinformatics and Chemoinformatics: Key Technologies in the Drug Discovery Process
5 Target identification and validation in anti parasitic drug discovery
6 Selective Drug Targets in Parasites
7 Lessons Learned From Target Based Lead Discovery
8 Approaches towards Antiparasitic Drug Candidates for Veterinary Use
9 Learning to Relate Structural Space with Property Space
10 Recruiting the Host Defense Mechanisms: Roles for Vaccines and Chemotherapeutics
PART II Protozoan Parasites
11 Proteases of Parasitic Protozoa -
Current Status and Validation
12 In Search of Trypanocidal Drugs
13 Trypanosomatid protein kinases as potential drug targets
14 Targeting the malaria kinome; discovering kinase inhibitors as novel antimalarial agents
15 Malaria and anti-malarials - a focused view
PART III Multicellular Parasites
16 Chemotherapeutic development strategies for schistosomiasis
17 Searching new Anti-Parasitics in the Virtual Space
18 Cyclooctadepsipeptides - an anthelmintically active class of compounds exhibiting a novel mode of action
19 Chemical Optimization of Anthelmintic Compounds - a Case Study
PART IV Bacteria
20 Pathogenomics: identification of novel drug targets and vaccine candidates in bacteria
21 Tuberculosis Drug Discovery: Issues, Gaps and the Way Forward
22 Decreasing the number of gaps in the draft assembly of the Mannheimia haemolytica M7/2 genome sequence
23 Total synthesis and configurational assignment of pasteurestin A and B, a natural product with antimicrobial acitivty on Pasteurellaceae
Aus erster Hand berichten die Autoren der Beiträge dieses Bandes, mit welchen Strategien in der kommerziellen Forschung nach Wirkstoffen gegen Infektionskrankheiten gesucht wird. Dabei konzentrieren sie sich in erster Linie auf Parasitosen, berücksichtigen aber auch bakterielle Infektionen. Hochinteressante Informationen, die man in dieser Form nirgends findet! Addressing parasitic diseases and those caused by bacteria, this much needed reference and handbook provides a unique insight into the approach adopted by commercial science towards infectious diseases, including the work of medicinal chemists. Many of the authors are scientists with hands-on experience of drug discovery units within the pharmaceutical industry. In addition, the text covers efforts towards drug development in infectious diseases from academic groups and non profit organizations.
Editiert von: Paul M. Selzer
Prof. Dr. Paul M. Selzer studied Biology, Parasitology, and Biochemistry at the University of Tübingen, Germany, where he also received his PhD in Biochemistry. He spent three years in the parasitology and tropical disease laboratory of Prof. James H. McKerrow at the University of California, San Francisco (UCSF). During his professional career he worked as researcher and scientific manager for several pharmaceutical companies, being currently employed by Intervet Innovation GmbH, Germany, part of a leading Animal Health company. Dr. Selzer is also a visiting Professor and teacher in Biochemistry, Bioinformatics, and Chemoinformatics at the University of Tübingen, and holds an Honorary Professorship in the Department of Infection and Immunity at the University of Glasgow, UK.

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Autor: Paul M. Selzer
ISBN-13:: 9783527323272
ISBN: 3527323279
Erscheinungsjahr: 01.04.2009
Verlag: Wiley VCH Verlag GmbH
Gewicht: 1093g
Seiten: 489
Sprache: Englisch
Sonstiges: Buch, 247x182x30 mm, 150 schwarz-weiße und 33 farbige Abbildungen