Autor: Andrew W. Zimmerman
ISBN-13: 9781603274883
Veröffentl: 01.10.2008
Einband: Buch
Seiten: 474
Gewicht: 828 g
Format: 241x164x26 mm
Sprache: Englisch

Autism

Current Clinical Neurology
Current Theories and Evidence

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This book presents current theories about autism and the evidence that supports them. It reveals how the scientific method is identifying the biological bases of these disorders, leading the way to their treatment and prevention using evidence-based medicine.
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Table of ContentsPreface

Moving Beyond Hypotheses: A Call for Theories and Evidence

Andrew W. Zimmerman
I. Molecular and Clinical Genetics

Chapter 1

ENGRAILED2 and Cerebellar Development in the Pathogenesis of Autism Spectrum Disorders

Ian T. Rossman and Emanuel DiCicco-Bloom
Chapter 2

Teratogenic Alleles in Autism and Other Neurodevelopmental Disorders

William G. Johnson, Madhura Sreenath, Steven Buyske and Edward S. Stenroos
Chapter 3Cholesterol Deficit in Autism: Insights from Smith-Lemli-Opitz Syndrome

Alka Aneja and Elaine Tierney
Chapter 4

Autism in Genetic Intellectual Disability: Insight into the Bases and Features of Idiopathic Autism

Walter E. Kaufmann, George T. Capone, Megan Clarke and Dejan B. Budimirovic
II. Neurotransmitters and Cell Signaling

Chapter 5

Serotonin Dysfunction in Autism

Mary E. Blue, Michael V. Johnston, Carolyn Boylan Moloney and Christine F. Hohmann
Chapter 6

Excitotoxicity in Autism: The Role of Glutamate in Pathogenesis and Treatment

Martin Evers and Eric Hollander
Chapter 7

Prenatal Beta 2 Adrenergic Receptor Signaling and Autism: Dysmaturation and
Retained Fetal Function

Susan L. Connors
IV. Endocrinology, Growth and Metabolism

Chapter 8

A role for fetal testosterone in human sex differences: Implications for
Understanding autism

Bonnie Auyeung and Simon Baron-Cohen
Chapter 9

Interaction between Genetic Vulnerability and Neurosteroids in Purkinje cells as a Possible Neurobiological Mechanism in Autism Spectrum Disorders

Flavio Keller, Roger Panteri, Filippo Biamonte
Chapter 10

Insulin-like growth factors: Neurobiological regulators of brain growth in autism?

Raili Riikonen

Chapter 11

Oxidative Stress and the Metabolic Pathology of Autism

S. Jill James
V. Immunology, Maternal-Fetal Interaction and Neuroinflammation

Chapter 12

The Immune System in Autism: is there a Connection?

Luke Heuer, Paul Ashwood and Judy Van de Water

Chapter 13

Maternal Immune Activation, Cytokines and Autism

Paul H. Patterson, Wensi Xu, Stephen E. P. Smith and Benjamin E. Deverman
Chapter 14

Maternal Antibodies and the Placental-Fetal IgG Transfer Theory

Christina M. Morris, Mikhail Pletnikov, Andrew W. Zimmerman, and Harvey S. Singer
Chapter 15

Can Neuroinflammation Influence the Development of Autism Spectrum Disorders?

Carlos A. Pardo-Villamizar
VI. Neuroanatomy and Neural networks

Chapter 16

The Significance of Minicolumnar Size Variability in Autism: A Perspective from Comparative Anatomy

Manuel F. Casanova
Chapter 17

Imaging evidence for pathological brain development in Autism Spectrum Disorders

Stephen R Dager, Seth D Friedman, Helen Petropoulos and Dennis WW Shaw
Chapter 18

Information Processing, Neural Connectivity, and Neuronal Organization

Nancy J. Minshew, Diane L. Williams, a
Creative thinking and collaborative scientific research have advanced our understanding of autism, and we are now beginning to synthesize the data into evidence and theories. Autism: Current Theories and Evidence presents current theories about autism and the evidence that supports them. The goal is to show how the scientific method is revealing the biological bases of this spectrum of disorders, thereby leading the way to their treatment and prevention using evidence-based medicine. This book has 20 chapters divided into 6 sections: Molecular and Clinical Genetics; Neurotransmitters and Cell Signaling; Endocrinology, Growth and Metabolism; Immunology, Maternal-Fetal Effects and Neuroinflammation; Neuroanatomy, Imaging and Neural networks; and Environmental Mechanisms and Models. The subjects cover a wide range of current scientific work in the field of autism, with strong and growing evidence to support them, and demonstrate both the breadth and depth of current autism research. The reader is encouraged to consider how theories and the scientific method, in the hands of these and other dedicated researchers, are leading to greater knowledge and continued progress in autism research.
Editiert von: Andrew W. Zimmerman
RezensionFrom the reviews:"Autism: Current Theories and Evidence, edited by Andrew Zimmerman, serves as an atlas or geophysical study of the archipelago of autism. this book is a valuable contribution to the effort to map autism, and it is a demonstration of the type of cooperation that is needed across scientific disciplines if progress is to be made in this effort." (Jeffrey A. Munson, The New England Journal of Medicine, Vol. 360 (23), June, 2009)"All chapters are uniformely arranged with initial abstract, many informative subheadings, tables and impressive figures. All of them are clearly written. the present book provides an impressive, evidence-based review of pathogenesis, clinical features, genetics, biological bases, pathogenetic factors, current or future treatments of ASDs. It is therefore recommended to all clinicians and neuroscientist who are interested and engaged in the complex field of ASDs." (K. A. Jellinger, European Journal of Neurology, Vol. 16, 2009)"The book has 20 chapters divided into 6 parts. Mainly, but not only, for neurobiologists, psychologists and psychiatrists. Recommended." (Pediatric Endocrinology Reviews, Vol. 8 (2), December, 2010)

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Autor: Andrew W. Zimmerman
ISBN-13:: 9781603274883
ISBN: 160327488X
Erscheinungsjahr: 01.10.2008
Verlag: Springer-Verlag GmbH
Gewicht: 828g
Seiten: 474
Sprache: Englisch
Sonstiges: Buch, 241x164x26 mm, 8 farbige Abbildungen, 2 schwarz-weiße Fotos, 40 schwarz-weiße Zeichnungen, 24 schwarz-weiße Tabellen