Autor: Joseph D. Rosenblatt
ISBN-13: 9781461488088
Veröffentl: 01.11.2013
Einband: Book
Seiten: 371
Gewicht: 689 g
Format: 241x162x23 mm
Sprache: Englisch

Advances in Tumor Immunology and Immunotherapy

Current Cancer Research

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This book examines evolving paradigms in antigen presentation, dendritic cell biology, innate response and immunosuppressive mechanisms and strategies for manipulation of the immune system to treat neuroblastoma, leukemia, melanoma, lung cancer and more.
Inhaltsangabe- Clinical: Two decades of immunotherapy for melanoma and renal cell carcinoma what has been learned N. Restifo and S. Rosenberg or J. Economou /A Belldegrun Manipulation of costimulatory pathways in melanoma and other tumors L. Lanier or J. Allison Therapeutic targeting of heat shock pathways in lung and other tumors L.Raez and E. Podack and /or A. Srivastava The T regulatory cell as a therapeutic target: R. Levy or B. Blazar Clinical experience with newer cytokines TBN Graft vs leukemia and Graft Versus Host disease Therapeutic Manipulation of Allogeneic and Autologous Response following Transplantation K. Komanduri and R. Levy and/or B. Blazar Gene therapy for Head and Neck Cancer Giovanna Thomas and W. J. Goodwin Immune Targeting of Neuroblastoma R.Seeger Antibody Fusion Proteins in the Clinic P. Sondel and J. Rosenblatt Assessment of Response in Clinical trials new Clinical Endpoints TBN, T.Whiteside Basic: Biology of the cytolytic response in NK and T cells: E. Podack Biology of the innate response to tumors D Raulet or Tom Spies The role of B cells in shaping the immune response J.Rosenblatt and Y.D.Zhang Dendritic cell biology and tumor recognition and evasion James Mule Linking of the adaptive and innate response The NKG2D, TLR signaling . D.Raulet Interferon biology and defects in the tumor innate response G Barber Viral mechanisms of tumor evasion K. Tolba Viral targets for immune therapy M. Kast Negative regulation of the immune response T reg biology and suppression of the immune response E Shevach or Robert. Levy and/or Tom Malek T cell anergy A. Ochoa Myelosuppressor cells S. OstrandRosenberg PD1 TBA CTLA4 J. Allison or J. Bluestone TGFbeta R. Flavell B7 family of coinhibitors X. Zhang Tumor secreted factors D. Lopez Tumor microenvironment E. Gilboa Preclinical strategies Gene therapy VSV G. Barber Adenovirus TBN Retargeting via modified receptors: Z. Eschar T cell engineering using introduced T cell receptors N. Nishimura Activation of NK responses T. Spies or G.Weiner Bifunctional Antibodies and Antibody fusion proteins S.U.Shin, J.D.Rosenblatt and or L.Weiner Homeostatic T cell expansion B. Fox Adoptive T cell transfer C. June or P.Hoffman Therapeutic Targeting of Viral Antigens P.Hoffman? Donor Leukocyte Infusion, Graft versus Host Disease and Graft versus Leukemia K. Komanduri or R. Korngold Identification of Target Antigens for Immune TherapyTBN, Drew Pardoll?. Thierry Boon?
Contents

Part I Immune Activation, Suppression and Manipulation of the Immune Antitumor Response

Myeloid-Derived Suppressor Cells in Cancer.....Christos E. Kyriakopoulos, Alberto J. Montero, and Claudia Marcela Diaz-Montero

The Role of B Cells in Shaping the Antitumor Immune Response......Yu Zhang, Taylor H. Schreiber, and Joseph D. Rosenblatt

Heat-Shock Protein-Based Cancer Immunotherapy.....Taylor H. Schreiber

Activation of NK Cell Responses and Immunotherapy of Cancer......George J. Weiner

Induction of Tumor Immunity by Targeted Inhibition of Nonsense-Mediated mRNA Decay.....Eli Gilboa

Employing T Cell Homeostasis as an Antitumor Strategy.....Shawn M. Jensen, Christopher C. Paustain, and Bernard A. Fox

Adoptive Cell Therapy of Systemic Metastases Using erbB-2-Specific T Cells Redirected with a Chimeric Antibody-Based Receptor.....Dinorah Friedmann-Morvinski, Tova Waks, Assaf Marcus, and Zelig Eshhar

Part II Evolving Clinical Immunotherapeutic Strategies

Immunotherapy in Renal Cell Carcinoma.....Jennifer Cudris and Jaime R. Merchan

Adoptive T-Cell Transfer as a Clinical Antitumor Strategy for Hematologic Malignancies......Aaron P. Rapoport and Nadia Ijaz

Bifunctional Antibodies: Preclinical and Clinical Applications.....Casey W. Shuptrine and Louis M. Weiner

Clinical Development of Antibody-Fusion Proteins for Cancer Therapy.....Kory L. Alderson, Amy K. Erbe, Margaret Boyden, and Paul M. Sondel

Immunologic Outcomes of Allogeneic Stem Cell Transplantation: Graft-Versus-Host and Graft-Versus-Leukemia Responses and Implications for Future Therapy.....Lazaros J. Lekakis and Krishna V. Komanduri

The Immune System in Head and Neck Squamous Cell Carcinoma: Interactions and Therapeutic Opportunities.....Paolo Serafini and Donald T. Weed

T Cell Co-regulatory Signals and Their Role in Cancer Therapy......Eitan R. Friedman, Lynn Feun, Pasquale Benedetto, and Joseph D. Rosenblatt

Assessment of Immune Response in Biotherapy Trials and Clinical Endpoints.....Theresa L. Whiteside

Index
Recent advances in understanding of fundamental immunology have created new insights into the dynamic interactions between tumors and the immune system. This includes new understanding of T- and B-cell interaction, immune inhibitory mechanisms including the biology of T regulatory cells, myeloid suppressor cells, and dendritic cell subsets.
Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppressive cytokines, defective innate and interferon response pathways, and NKG2D downregulation have all provided new insight into suppression of anti-tumor immunity and tumor evasion.

In addition to emerging understanding of tumor evasion, new immune targets such as CTLA4 blockade, NK stimulatory receptors, manipulation of the antigen processing and presentation, cytokine and costimulatory responses all provide new possibilities for enhancing anti-tumor immunity even in tumors previously felt to be resistant to immune attack. Several of these strategies have already been realized in the clinic. The volume will explore evolving paradigms in antigen presentation, dendritic cell biology, the innate response and immunosuppressive mechanisms, and emerging strategies for manipulation of the immune system for therapeutic benefit that have realized success in neuroblastoma, leukemia, melanoma, lung cancer, and allogeneic transplantation. Early successes as well as failures will be highlighted to provide a snapshot of the state of clinical immunotherapy with an eye to future possibilities such as combination therapies, adoptive T-cell transfer, and the retargeting of immune cells via T-cell receptor engineering.

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Autor: Joseph D. Rosenblatt
ISBN-13:: 9781461488088
ISBN: 1461488087
Erscheinungsjahr: 01.11.2013
Verlag: Springer-Verlag GmbH
Gewicht: 689g
Seiten: 371
Sprache: Englisch
Sonstiges: Buch, 241x162x23 mm, 80 schwarz-weiße und 16 farbige Abbildungen