Autor: Benjamin Bonavida
ISBN-13: 9781461470694
Veröffentl: 31.05.2013
Einband: Book
Seiten: 260
Gewicht: 544 g
Format: 244x159x22 mm
Sprache: Englisch

Tumor Cell Resistance In Cytotoxic Drug-Induced Apoptosis

Resistance to Targeted Anti-Cancer Therapeutics
Targeting Sensitizing Agents

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This book surveys current advances in understanding the mechanisms of cancer cell resistance to apoptotic stimuli, which eventually result in cancer progression and metastasis. Developments presented here may help improve clinical response to resistant tumors.
¿¿¿¿¿¿¿¿¿¿Describes the main mechanisms that govern tumor cell resistance to apoptotic stimuli

Demonstrates the identification of existing agents or the development of new agents that can serve as sensitizing agents with other cytotoxics

Features the latest research on the results of combining targeted sensitizing agents and conventional cytotoxic therapies
Part I. Mechanism of tumor cell resistance to cytotoxic apoptosis drugs: Innate versus induced1. Molecular pathway of apoptosis
2. Molecular anti-apoptotic pathways in cancer
3. Genetic mechanisms that regulate resistance
4. Oncogenesis and tumor cell resistance
5. Molecular heterogeneity of various cancers and cancer stem cells in resistance
6. Molecular signature profiles of resistance in cancers
Part II. Dominant pathways and gene products that regulate resistance 7. Resistant targets for apoptosis
8. Autocrine and Paracrine factors
9. Oncogenes
10.Tumor micro environment
Part III. Selective agents that target resistant mechanisms: Direct and indirect
11. Proteasome inhibitors
12. Chemicals: free and encapsulated in nanoparticles
13. Receptor agonists and antagonists
14. Antibodies
_____This volume gives the latest developments in on the mechanisms of cancer cell resistance to apoptotic stimuli, which eventually result in cancer progression and metastasis. One of the main challenges in cancer research is to develop new therapies to combat resistant tumors. The development of new effective therapies will be dependent on delineating the biochemical, molecular, and genetic mechanisms that regulate tumor cell resistance to cytotoxic drug-induced apoptosis. These mechanisms should reveal gene products that directly regulate resistance in order to develop new drugs that target these resistance factors and such new drugs may either be selective or common to various cancers. If successful, new drugs may not be toxic and may be used effectively in combination with subtoxic conventional drugs to achieve synergy and to reverse tumor cell resistance. The research developments presented in this book can be translated to produce better clinical responses to resistant tumors.
Editiert von: Benjamin Bonavida
Dr. Benjamin Bonavida is a professor at UCLA's David Geffen School of Medicine for the Department of Microbiology, Immunology, & Molecular Genetics. His other appointments include being a member of the Department of Defense Congressionally Directed Medical Research Program, Member of the National Cancer Institute's SPORE Program, member of the International Scientific Advisory Board of the Israel Cancer Research Foundation, to name a few. He's currently a scientific reviewer for several journals and a member of editorial boards including Journal of Clinical Immunology, International Journal of Oncology, and Cancer Biotherapy & Radiopharmaceuticals. In his career, he's published over 450 papers and reviews, and he's also edited two books with Springer in the past. For more information, please see the CV attached herewith.

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Autor: Benjamin Bonavida
ISBN-13:: 9781461470694
ISBN: 1461470692
Erscheinungsjahr: 31.05.2013
Verlag: Springer-Verlag GmbH
Gewicht: 544g
Seiten: 260
Sprache: Englisch
Sonstiges: Buch, 244x159x22 mm, 25 farbige Abbildungen