Autor: Enrique Cadenas
ISBN-13: 9780123813459
Veröffentl: 01.07.2010
Einband: Buch
Seiten: 416
Gewicht: 821 g
Format: 234x159x28 mm
Sprache: Englisch

Thiol Redox Transitions in Cell Signaling, Part A

473, Methods in Enzymology Academic Press
Chemistry and Biochemistry of Low Molecular Weight and Protein Thiols

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Presents methods and protocols dealing with thiol oxidation-reduction reactions and their implications as they relate to cell signaling. This book deals with glutathionylation and dethiolation,and peroxide removal by peroxiredoxins/thioredoxins and glutathione peroxidases.
Editiert von: Enrique Cadenas, Lester Packer
ENRIQUE CADENAS, MD, PhD, received his PhD in biochemistry from the University of Buenos Aires, School of Medicine. He is professor of pharmacology and pharmaceutical sciences at the University of Southern California School of Pharmacy and of biochemistry and molecular biology at the University of Southern California Keck School of Medicine, and doctor honoris causa (medicine) at the University of Link ping, Sweden. Cadenas was president of the Society for Free Radical Research International (SFRRI) and is fellow of the Society for Free Radical Biology & Medicine. He served the scientific community by participating on NIH study sections (2002-2006; chair 2006-2008). His research interests include energy and redox metabolism in brain aging and the coordinated inflammatory-metabolic responses in brain and neurodegenerative diseases. Lester Packer received a PhD in Microbiology and Biochemistry in 1956 from Yale University. In 1961, he joined the University of California at Berkeley serving as Professor of Cell and Molecular Biology until 2000, and then was appointed Adjunct Professor, Pharmacology and Pharmaceutical Sciences, School of Pharmacy at the University of Southern California. Dr Packer received numerous distinctions including three honorary doctoral degrees, several distinguished Professor appointments. He was awarded Chevalier de l'Ordre National du Merite (Knight of the French National Order of Merit) and later promoted to the rank of Officier. He served as President of the Society for Free Radical Research International (SFRRI), founder and Honorary President of the Oxygen Club of California. He has edited numerous books and published research; some of the most cited articles have become classics in the field of free radical biology: Dr Packer is a member of many professional societies and editorial boards. His research elucidated - the Antioxidant Network concept. Exogenous lipoic acid was discovered to be one of the most potent natural antioxidants and placed as the ultimate reductant or in the pecking order of the "Antioxidant Network regenerating vitamins C and E and stimulating glutathione synthesis, thereby improving the overall cellular antioxidant defense. The Antioxidant Network is a concept addressing the cell's redox status. He established a world-wide network of research programs by supporting and co-organizing conferences on free radical research and redox biology in Asia, Europe, and America.

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Autor: Enrique Cadenas
ISBN-13:: 9780123813459
ISBN: 012381345X
Erscheinungsjahr: 01.07.2010
Verlag: Elsevier LTD, Oxford
Gewicht: 821g
Seiten: 416
Sprache: Englisch
Sonstiges: Buch, 234x159x28 mm, Illustrations (some col.)